Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred.īurn, treatment: Infants >2 months, Children, and Adolescents: Limited data available in infants and children: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed burned area should be covered with cream at all times (Caruso 2006 de Graaf 2016, Schonfeld 1990) Administrationįor topical use only avoid contact with eyes. Note: Continue use until healing has occurred or the burn site is ready for grafting. Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred. Continue use until healing has occurred or the burn site is ready for grafting. Dosage and Administration Dosing: Adultīurn treatment: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed to areas where the cream is removed by patient activity as the burned area should be covered with cream at all times. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty. Hypersensitivity to silver sulfadiazine or any component of the formulation pregnant women approaching or at term premature infants or neonates ≤2 months of age.ĭocumentation of allergenic cross-reactivity for drugs in this class is limited. Sulfadiazine: ~24 hours (Sano 1982) Use: Labeled Indicationsīurn treatment: As an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Silver: Feces slow excretion rate Sulfadiazine: Urine (6.6% within 5 days) (Sano 1982) Half-Life Elimination Negligible (superficial and deep burns and normal skin) increased absorption with blister removal (Sano 1982) Excretion Active against Pseudomonas aeruginosa, Pseudomonas maltophilia, Enterobacter species, Klebsiella species, Serratia species, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Providencia species, Citrobacter species, Acinetobacter calcoaceticus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus species, Candida albicans, Corynebacterium diphtheriae, and Clostridium perfringens Pharmacokinetics/Pharmacodynamics Absorption Bactericidal for many gram-negative and gram-positive bacteria and is effective against yeast. Acts upon the bacterial cell wall and cell membrane.
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